Reparixin, a CXCR1/2 inhibitor in islet allotransplantation
نویسندگان
چکیده
منابع مشابه
Human islet allotransplantation in 18 diabetic patients.
Nineteen mtrahepatic islet allografts were performed in 18 patients. In group I. nine patients aged 8 to 58 years underwent (ombined liver-Islet allotransplantation following upper-abdominal exenteration for tumors too extensive to be removed with less drastic procedures.b•7 Preliminary results on these patients have been reponed previously.~ In group 2. three type I diabetic patients aged 22 t...
متن کاملDetection of pancreatic islet tissue following islet allotransplantation in man.
Qualitative and quantitative standards have been recently proposed for islet isolation asaeument in humans and large animals ( 1). The ultimate test of viability is functional activity after transplantation into a diabetic recipient. Morphologic identification of insulin-containing transplanted islets could provide important correlative data and eventually confmn the functional results. Recentl...
متن کاملPrediction of clinical outcome in islet allotransplantation.
R ecent progresses in the pancreas’ enzymatic digestion process along with novel immunosuppression strategies have led to successful clinical trials of islet transplantation in humans. On the other hand, clinical outcome remains variable and unpredictable in centers with limited experience. The possibility of predicting in vivo islet graft function should allow the selection of preparations on ...
متن کاملA preclinical evaluation of alternative site for islet allotransplantation
The bone marrow cavity (BMC) has recently been identified as an alternative site to the liver for islet transplantation. This study aimed to compare the BMC with the liver as an islet allotransplantation site in diabetic monkeys. Diabetes was induced in Rhesus monkeys using streptozocin, and the monkeys were then divided into the following three groups: Group1 (islets transplanted in the liver ...
متن کاملHuman islet isolation and allotransplantation in 22 consecutive cases.
This report provides our initial experience in islet isolation and intrahepatic allotransplantation in 21 patients. In group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer. In group 2, 4 patients received a combined liver-islet allograft for cirrhosis and diabetes. One patients had plasma C-peptide greater than 3 pM and was th...
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ژورنال
عنوان ژورنال: Islets
سال: 2016
ISSN: 1938-2014,1938-2022
DOI: 10.1080/19382014.2016.1199303